My Best Friend Is Invisible was adapted into an episode of the Goosebumps TV series. It premiered on Fox Network on September 8th, 1997, as the second episode of Season 3, and the forty-sixth episode overall. It was directed by William Fruet.
- Jon Davey as Sam Jacobs
- Dalene Irvine as Roxanne
- Darcy Weir as Brent Green
- Ted Simonett as Norman Jacobs
- Arlene Mazerolle as Beverly Jacobs
- Vickie Papavs as "Teacher"
- K. Trevor Wilson as "Kid #1"
- Kamil Orzechowski as "Kid #2"
Differences from the Book
- Simon and Brutus were absent in the episode.
- Brent does not mention why he does not make himself known to Roxanne; nor does Sammy offer Brent to be friends with Roxanne instead.
- The episode mentions that humans should have all been captured by aliens like that are like Sammy.
- In the book, Sammy and his family are aliens who have tentacles and slimy skin. In the television adaptation, they're humans who have faces in the back of their heads.
- The surprise ending in the episode is mostly different than the one in the book. Even though the twist that Sammy and his family are aliens and that Brent is the last human left on Earth who has to be invisible in order to avoid capture was kept, the book version ends with Brent being taken back to an intergalactic zoo where all the humans are kept. The TV version is a bit more menacing. It implies that Sammy and his family are the aliens who invaded Earth and got rid of all humans (except for Brent).
- This is the only Season 3 episode that originally aired with the Season 2 theme. Later, when the episode ran in syndication, the theme was corrected.
- The media playing on the television when Sam wakes up is the Goosebumps episode, The Scarecrow Walks at Midnight.
- Hedge House was first Freddy and Cara's house and then Jeff and Kim's house with the inside redressed.