- Kyle Labine as Evan Ross
- Sarah Podemski as Andy
- Corinne Conley as Aunt Katherine
- Joy Tanner as Sarabeth
- Mark Benesh as Curtis
- Mark Melymick as Dad
- Janet Land as Mom
- Ashley Dawn Brown as Julia (uncredited)
Differences from the book
- Evan and Andy find the Monster Blood in a room Kathryn forbid them from entering. In the book, they bought a can of Monster Blood at an old toy store.
- Trigger is a collie mix instead of a cocker spaniel.
- The twin bullies were omitted.
- Kathryn is not deaf.
The Monster Blood DVD was released in 2008 to celebrate the release of Goosebumps HorrorLand, and was released alongside the A Night in Terror Tower and One Day at HorrorLand DVDs. The DVD features the following episodes: